The eukaryotic genome is a mosaic of eubacterial and archaeal genes in addition to those unique to itself. The mosaic may have arisen as the result of two prokaryotes merging their genomes, or from genes acquired from an endosymbiont of eubacterial origin. A third possibility is that the eukaryotic genome arose from successive events of lateral gene transfer over long periods of time. This theory does not exclude the endosymbiont, but questions whether it is necessary to explain the peculiar set (...) of eukaryotic genes. We use phylogenetic studies and reconstructions of ancestral first appearances of genes on the prokaryotic phylogeny to assess evidence for the lateral gene transfer scenario. We find that phylogenies advanced to support fusion can also arise from a succession of lateral gene transfer events. Our reconstructions of ancestral first appearances of genes reveal that the various genes that make up the eukaryotic mosaic arose at different times and in diverse lineages on the prokaryotic tree, and were not available in a single lineage. Successive events of lateral gene transfer can explain the unusual mosaic structure of the eukaryotic genome, with its content linked to the immediate adaptive value of the genes its acquired. Progress in understanding eukaryotes may come from identifying ancestral features such as the eukaryotic splicesome that could explain why this lineage invaded, or created, the eukaryotic niche. BioEssays 28:57–64, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

In its comprehensive overview of Alain Locke's pragmatist philosophy this book captures the radical implications of Locke's approach within pragmatism, the critical temper embedded in Locke's works, the central role of power and empowerment of the oppressed and the concept of broad democracy Locke employed.

So far as philosophizing is concerned with another's thoughts, it is criticizing. No true philosopher, as such, merely accepts or merely reproduces, another's thoughts. The true philosopher starts anew — independently, solitarily. But his understanding of the work done by others can make his own philosophizing surer and quicker. He must see for himself. But sometimes he can more easily avoid the pitfalls that others have discovered and marked. Thus, in the social history of philosophizing there can be not only (...) mere repetition and mere novelty, but also progress. Even the less able philosopher may improve on the results of a more able predecessor. (shrink)

McDonald's thesis is that the chief villain in the unfolding tragedy of Canada is Pierre Elliott Trudeau and, to a lesser extent, his predecessor Lester B. Pearson. Goldwin Smith's well-known late-19th century comment that Canada was “rich by nature, but poor by policy” seems to hold true today. The secondlargest country in the world, rich in resources, Canada has been virtually bankrupted by government profligacy. Canada has been called “the impossible country,” and many have considered it “an impossible country (...) to govern.” The accumulated national debt is now reaching 600 billion in Canadian dollars (one Canadian dollar equals about $.72 US), which per capita is six times that of the US. (shrink)

This study investigates Félix RavaissonRavaisson-Mollien, Félix’s ambiguous relation to F. W. J. Schelling by homing in on the specific relation that holds between habit as a means of demonstrating an underlying identity of mind and world in RavaissonRavaisson-Mollien, Félix’s De l’habitude and Schelling’s use of aesthetic intuitionIntuition as a philosophical method in his 1800 System of Transcendental IdealismIdealism (also German Idealism). I argue that what Schelling found in fine art—the work of genius—RavaissonRavaisson-Mollien, Félix finds in habit, and from this conclude (...) that RavaissonRavaisson-Mollien, Félix offers what we might describe as a romantic conception of habit that brings it into the domain of the pre-rational, pre-reflective spontaneity that Schelling describes in artistic production. (shrink)

Hume's Reception in Early America: Expanded Edition brings together the original American responses to one of Britain's greatest men of letters, David Hume. Now available as a single volume paperback, this new edition includes updated further readings suggestions and dozens of additional primary sources gathered together in a completely new concluding section. From complete pamphlets and booklets, to poems, reviews, and letters, to extracts from newspapers, religious magazines and literary and political journals, this book's contents come from a wide variety (...) of sources published in colonial America and the early United States between 1758 and 1850. As well as classics by Thomas Jefferson, John Adams and Alexander Hamilton, it contains scores of unknown and hard-to-locate items, many of which have not been reprinted since their original publication. These responses are divided into four parts covering Hume's Essays; his Philosophical Writings; his History of England; and his Character and Death. Each of those parts has a separate introductory essay, and every selection is introduced by a short headnote that sets the piece in its historical context and provides bibliographical references. Packed with new insights into Hume and American thought and culture, Hume's Reception in Early America reveals the relevance and impact of Hume on American political, philosophical, historical, religious, and aesthetic debates. (shrink)

In this book Mark Wynn argues that the landscape of philosophical theology looks rather different from the perspective of a re-conceived theory of emotion. In matters of religion, we do not need to opt for objective content over emotional form or vice versa. On the contrary, these strategies are mistaken at root, since form and content are not properly separable here - because 'inwardness' may contribute to 'thought-content', or because emotional feelings can themselves constitute thoughts; or because, to put (...) the point a further way, in religious contexts, perception and conception are often infused by feeling. Wynn uses this perspective to forge a distinctive approach to a range of established topics in philosophy of religion, notably: religious experience; the problem of evil; the relationship of religion and ethics, and religion and art; and in general, the connection of 'feeling' to doctrine and tradition. (shrink)

The essays in this collection all treat in some way the conservative’s vision of society as it is variously manifested in literary art, its scholarship, and its transmission through classical modes of liberal learning. Responding in part to the postmodernist turn in literary study, Literature and the Conservative Ideal examines the ways in which conservatism has been depicted in literature, as well as how its tendencies might restore literature’s potential as an artistic reflection of the universal human condition.

Critics of reliability theories of epistemic justificationoften claim that the `generality problem' is an insurmountabledifficulty for such theories. The generality problem is theproblem of specifying the level of generality at which abelief-forming process is to be described for the purposeof assessing its reliability. This problem is not asintractable as it seems. There are illuminating solutionsto analogous problems in the ethics literature. Reliabilistsought to attend to utilitarian approaches to choices betweeninfinite utility streams; they also ought to attend towelfarist approaches to social (...) choice situations that donot demand full aggregation of individual welfares.These analogies suggest that the traditional `single number'approach to reliability is misguided. I argue that a newapproach – the `vector reliability' approach – is preferable.Vector reliability theories associate target beliefs withreliability vectors – that is, structured collections ofreliability numbers – and construct criteria of epistemicjustification that appeal to these vectors. The bulk of thetheoretical labor involved in a reliability account of epistemicjustification is thus transferred from picking a uniquereliability number to constructing a plausible criterionof epistemic justification. (shrink)

Critics of reliability theories of epistemic justificationoften claim that the `generality problem' is an insurmountabledifficulty for such theories. The generality problem is theproblem of specifying the level of generality at which abelief-forming process is to be described for the purposeof assessing its reliability. This problem is not asintractable as it seems. There are illuminating solutionsto analogous problems in the ethics literature. Reliabilistsought to attend to utilitarian approaches to choices betweeninfinite utility streams; they also ought to attend towelfarist approaches to social (...) choice situations that donot demand full aggregation of individual welfares.These analogies suggest that the traditional `single number'approach to reliability is misguided. I argue that a newapproach – the `vector reliability' approach – is preferable.Vector reliability theories associate target beliefs withreliability vectors – that is, structured collections ofreliability numbers – and construct criteria of epistemicjustification that appeal to these vectors. The bulk of thetheoretical labor involved in a reliability account of epistemicjustification is thus transferred from picking a uniquereliability number to constructing a plausible criterionof epistemic justification. (shrink)

In November 2018 the American Society for Bioethics and Humanities (ASBH) administered the first Healthcare Ethics Consultant Certification examination to 138 candidates, 136 of whom (98.5 percent) passed and were “certified” as “healthcare ethics consultants.” I believe this certification process is both premature and inadequate.Certification for ethics consultants is premature because, as Kornfeld and Prager state repeatedly in their article in this issue of The Journal of Clinical Ethics, “The Clinician as Clinical Ethics Consultant: An Empirical Method of Study,” there (...) is a lack of “empirical data on the nature of the problems that prompt ethics consultation requests and on the functions required to address them.” These authors proceed to provide a model for the kind of empirical data collection that is needed.Even more relevant, the ASBH model that certifies clinical ethics consultants is inadequate. First, it is inappropriate for a nonclinical organization such as the ASBH to claim the right to certify a clinical process, ethics consultation, involving patients and health professionals. Second, the current certification process requires only a written examination in contrast to the two-step quality attestation process proposed in 2013 by Eric Kodish, MD, and 11 other senior members of the ASBH, including its then president.Third and most importantly, the eligibility criteria for being certified to work on hospital units and to make clinical recommendations for patients and families are minimal and insufficient. The only stated requirements are a bachelor’s degree and 400 hours of healthcare ethics consulting experience. By contrast, practicing physicians and nurses train for many years to gain clinical experience that enables them to apply clinical ethical standards in the care and management of all inpatients and outpatients, not just the small percent for whom an ethics consultation is requested. (shrink)

Martin Heidegger’s Being and Time (1927) challenged earlier thinking about the basic structures of human being, our involvement in practical affairs, and our understanding of history, time, and being. Blitz clarifies Heidegger’s discussions, offers alternative analyses of phenomena central to Heidegger’s argument, and examines the connection between Heidegger’s position in Being and Time and his support of Nazism. As Blitz explains in his new afterword, “When I began to study Martin Heidegger nearly fifty years ago, my goal was to explore (...) the meaning of Being and Time for political philosophy. I wished to discover what it might offer for clarifying the grounds on which the basic concepts and alternatives of political philosophy rest. Would a close reading of it help us understand the questions of justice, freedom, the common good, natural rights, virtue, human happiness, and the philosophic life? These questions are as important today as they were then.” Although Blitz often questions and criticizes Heidegger’s views, he presents them with scrupulous care and clarity. Specialists and students in the areas of political theory, phenomenology, metaphysics, and moral philosophy will find Heidegger’s Being and Time & the Possibility of Political Philosophy an invaluable resource. (shrink)

In this paper I aim to clarify Hegel's objection to the use of ideals in ethical thinking by examining his opposition to Kant's ideal of perpetual peace. I explain why Hegel believes that the ideal of peace amounts to nothing more than a moral condemnation that ignores the significance for international relations of appreciating the modern nation-state as an ethical achievement. I argue, however, that Kant's proposed federation can be grounded in the concrete ethical realities Hegel accepts as compelling and (...) uses this basis to sketch a defensible understanding of the obligating force of ethical ideals against Hegel's objections. (shrink)

TWO FACETS OF HEGEL’S ETHICAL PHILOSOPHY become clear on close inspection. On the one hand, Hegel attempts to take advantage of the Kantian focus on autonomy as the ground for ethical obligation and build an account of Right in terms of free self-determining agency. On the other hand, once the account is in, it looks and feels quite different from Kant’s, emphasizing social institutions and history in ways that are distinctive to Hegel. How far do these Hegelian emphases pull us (...) from Kant? Are they simply an essential corrective of the Kantian project, as some Hegelians would like to claim? Or does Hegel end up with a view that is significantly antithetical to a Kantian position? In this paper I do not intend to address such questions comprehensively. Rather, I would like to touch on such questions by exploring a particular issue that seems to me of central importance to answering them. (shrink)

In this paper I argue that only a subset of the reason statementsWilliams defines as external must be rejected as false. `A has areason to '' is necessarily false when the ends and aimsconstitutive of A''s good close off the deliberative route from her S to the conclusion she has reason to . But when less important ends are at stake, it seems that a person''s needs generally provide reasons for action, contrary to Williams''s internalist account. I suspect, however, that (...) there may remain inexorable disagreementover these claims because people value things in two distinct ways. Tosupport my suspicion, I explain how people''s valuation can take either an agency-prioritizing or an end-prioritizing form. I then argue thatresolving the disagreement over Williams''s internalist account ofreasons depends on whether it can be established that the agency-prioritizingform is the rationally superior form of valuation. (shrink)

Plutarch’s epistolary essay, That a Philosopher ought to Converse especially swith Men in Power, has been neglected because not recognized for what it is: an attempt to persuade an addressee attached to Epicurean principles that his attraction to political friendship should be honoured rather than eradicated. Rather than attack Epicureanism, Plutarch attempts to expand the horizons of a hedonic and utilitarian ethics so as to include noble benefaction on a political scale. This requires him to undermine the Epicurean insistence on (...) restricting friendship to private like-minded circles, and to expand its hedonism into a political utilitarianism. Unlike Cicero’s De Finibus, Plutarch’s letter offers an indirect critique, and preserves elements of Epicurean ethics suitable to the moderating influence a friend and advisor can exert on the statesman’s eros. (shrink)

Philosophers from Plato and Augustine to Heidegger, Nozick, and Baudrillard have warned us of the dangers of living on too heavy a diet of illusion and make-believe. But contemporary cultural life provides broader, more attractive opportunities to do so than have existed at any other point in history. The gentle forms of self-deceit that such experiences require of us, and that so many have regarded as ethically unwholesome or psychologically self-destructive, can in fact serve as vital means to political reconciliation, (...) cultural enrichment, and even (a kind of) utopia. -/- The first half of the book provides a highly schematic definition of simulated experience and compares it with some claims about the nature of simulation made by other philosophers about what it is for one thing to be a simulation of another. The author then provides a critical survey of the views of some major authors about the value of certain specific types of simulated experience, mainly in order to point out the many puzzling inconsistencies and ambiguities that their thoughts upon the topic often exhibit. In the second half of the book, the author defends an account of the positive social value of simulated experience and compares his own position to the ideas of a number of utopian political thinkers, as well as to Plato's famous doctrine of the "noble lie." He then makes some tentative practical suggestions about how a proper appreciation of the value of simulated experience might influence public policy decisions about such matters as the justification of taxation, paternalistic "choice management," and governmental transparency. (shrink)

In his book The Existence of God , Professor Swinburne develops a cumulative case for theism. As part of this case, he presents two forms of the argument from design, one form taking as its premise the fact of spatial order, the other proceeding from the fact of temporal order. In this paper, I shall concern myself with the second of these arguments; that is, in Swinburne's terms, I shall concern myself with the argument from regularities of succession.

Several authors have recently attempted to provide a physicalist analysis of causation by appealing to terms from physics that characterise causal processes. Accounts based on forces, energy/momentum transfer and fundamental interactions have been suggested in the literature. In this paper, I wish to show that the former two are untenable when the effect of enclosed electromagnetic fluxes in quantum theory is considered. Furthermore, I suggest that even in the classical and non-relativistic limits, a theory of fundamental interactions should not be (...) reduced to either a theory of forces or of energy/momentum transfer, but should be understood as a classical account of mutual interactions. Causal links are therefore correctly characterised by generalised potentials. This leads to some speculation regarding the fundamental ontology of interactions and, in particular, the role of the quantum mechanical phase. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:238 HISTORY OF PHILOSOPHY that enigmatic Swiss iatrochemist sympathetically. In any event, Dr. King's sympathetic approach to Paracelsus manages to throw considerable light on the Paracelsian advice to all future physicians: Don't read books! Read the stars, but read them "in Neo-Platonic fashion" (p. 114)! While the author is "judicious" about Galen and Paracelsus in particular, he is far from being so when it comes to Friedrich Hoffmann, a (...) medical materialist and "systematist" from Halle in the eighteenth century. Paradoxically enough, Dr. King has a marked antipathy for the doctor of "sympathy " himself (p. 173). Incidentally, the only other physician in the book who is not liked--apparently for his being polemical (p. 215)--is a famous fellow-pathologist of the last century, Rudolf Virchow. Still, it is only fair to add that the author acknowledges fully Virchow's important contributions to the field of cellular pathology. Finally, Dr. King not only has his likes and dislikes as to the medical men he actually selects from modern medicine to represent changes in theory of disease, but he seems also to have a definite bias in another and more serious sense. With the exception of the Epilogue and Chapter IV, which includes Vesalius and Harvey as well as Hoffmann, all the episodes of modern medicine deemed worthy of study derive from the Germanic world. Curiously enough, although there is no discussion of the germ theory of disease as such in the book, there is mention of Koch, but not of Pasteur. And French physiologist Claude Bernard, the great medical philosopher who tried to do in the nineteenth century for scientific medicine what American pathologist Lester King is attempting in the twentieth, is conspicuous by his absence in The Growth of Medical Thought. PATRICKROMANELL University of Oklahoma Siimtliche Werke von Plato. (Reinbeck b. Hamburg: Rowohlt, 1959-1963. 6 volumes -- Rowohlts Klassiker der Literatur und der Wissenschaft. Griechische Philosophie.) Diese Taschenbiicherausgabe enth~ilt die meisten der von Schleiermacher iibersetzten Dialoge und ffigt die Briefe, den Timaios, den Kritias und die Nomoi in der Obersetzung von H. und F. H. Miiller hinzu. Die Ordnung entspricht offenbar der von den Herausgebern (W. F. Otto, E. Grassi und G. Plamb/Sck) angenommenen chronologischen Reihenfolge. Ausgelassen sind: Minos, Alkibiades H und Theages, Nebenbuhler, Kleitophon und die Epinomis--offenbar weil sie die Herausgeber fiir unecht halten. Die Obersetzung einer Reihe von Dialogen (bes. Parmenides, Politikos, Philebos, Timaios, Kritias) wurde einer Durchsicht unterzogen; leider teilen uns BOOK REVIEWS 239 die Herausgeber nicht mit, von wem. Jedem Dialog geht eine Gliederung voran; jeder Band ist mit einer recht brauchbaren Bibliographie versehen. Es ist erstaunlich zu erfahren, dass der erste Band, erstmalig in 1957 erschienen, in 1963 eine Auflage von 78000 erreicht hat; bleiben auch die Auflageziffern der fibrigen B~inde dahinter zurfick, so sind sie doch genfigend eindrucksvoll. Man wfinscht, der Verlag m6chte doch, durch diesen Erfolg ermutigt, das nach Obgesagtem noch Fehlende--und dazu noch Platons Gedichte--in einem Erg~inzungsband bringen, wie immer man fiber die Echtheit der Stficke denkt. Der stilistische Unterschied zwischen den ~bersetzungen von Schleiermacher (erstmalig: 1804-1810) und von H. und F. H. Mfiller ist ausserordentlich. Dies ist nicht etwa auf die gr6ssere Sprachmeisterschaff Schleiermachers zurfickfiihren. Vielmehr liegt seiner Obersetzungsmethode eine h6chst interessante Theorie zugrunde (die F. A. Wolff, der Schleiermachers ~bersetzung verhShnt und Wilamowitz, der sie als ungeniessbar bezeichnet hatte, offenbar unbekannt war). Dieser Theorie zufolge ist es die Aufgabe des ~2bersetzers, den Leser besffindig daran zu erinnern, dass er nur eine l~bersetzung vor sich hat. Einem ~bersetzer, der sich brfistet, dass sich sein Text so liest, wie ihn der Autor geschrieben h~itte, wenn er in der Sprache des ~bersetzers und seines Publikums gedacht h~itte, sollte erwidert werden "Daffir bin ich dir so dankbar, wie ich es w~ire, wenn du mir das Bild eines Mannes zeigtest und sagtest--So wiirde er ausgesehen haben, wenn ihn mit seiner Mutter ein anderer Vater gezeugt h~tte." In anderen Worten: da sich Inhalt und Ausdruck nicht abtrennen lassen, sollte der f2bersetzer, start das Original seiner Sprache anzueignen, vielmehr--wir gebrauchen hier den bekannten Brechtschen Begriff--im Leser einen Verfremdungseffekt erzeugen. Wie man sieht, ist Schleiermachers ~3bersetzungstheorie jeder "rationalistischen " strikte... (shrink)

The paper examines three themes from the recent philosophical literature on place: the status of places as “concrete universals”; the narratively mediated agency of places; and the various ways in which human identity proves to be relative to place. I argue that these themes throw into new relief a set of correlative issues in philosophical theology concerning, respectively, God’s supra-individuality, God’s status as a final cause, and the divine grounding of human identity. On this basis, the paper proposes that knowledge (...) of place is analogous to, and partly constitutive of, knowledge of God. (shrink)

The concept and values of wilderness, along with the practice of wilderness preservation, have been under attack for the past several decades. In _Rethinking Wilderness_, Mark Woods responds to seven prominent anti-wilderness arguments. Woods offers a rethinking of the received concept of wilderness, developing a positive account of wilderness as a significant location for the other-than-human value-adding properties of naturalness, wildness, and freedom. Interdisciplinary in approach, the book combines environmental philosophy, environmental history, environmental social sciences, the science of ecology, (...) and the science of conservation biology. (shrink)

This chapter begins with a review of recent philosophical literature on religious experience, which has generally been concerned with experiences that focus on God or some other supernatural ‘thing’, and then considers other kinds of religious experience which should be of some interest for natural theology. It suggests that these kinds of religious experience invite a certain conception of God, namely, as an overarching meaning, rather than as a supernatural ‘object’, and also a correlative epistemology, one which gives due acknowledgement (...) to the sense-making capacities of the human body and of affective responses in particular. (shrink)

Contemporary epistemologists assume a view I call ‘comparabilism.’ They do not, however, argue for this view. I claim that noncomparabilism is a viable alternative. I further argue that noncomparabilism has advantages over comparabilism.

Two of the distinctive ethical issues that arise for computer users (as opposed to computer programmers) have to do with the file formats that are used to encode information and the licensing terms for computer software. With respect to both issues, most professional philosophers do not recognize the burdens that they impose on others. Once one recognizes these burdens, a very simple argument demands changes in the behavior of the typical computer user: some of the ways we use computers gratuitously (...) impose significant burdens on others; it is wrong to impose significant burdens on others gratuitously; some of the ways we use computers are unethical. (shrink)

In this paper, I consider the fruitfulness of the notion of supererogation for an understanding of the relationship between religious and secular ethics. I approach this theme in three ways. First, I note a contrast between the virtues of neighbour love and infused temperance, as they are represented in the work of Thomas Aquinas: in the first case, but not the second, appeal to religious context changes the status of an action, so that it is now obligatory when it would (...) otherwise have been supererogatory. I consider how we might explain this difference, and what it indicates about the distinctive character of a ‘religious ethic’. Next, I note how John of the Cross's account of the spiritual life, while tracking Aquinas's discussion on certain points, invites a more radical revision of the distinction between obligation and supererogation. Finally, and briefly, I argue that these reflections throw new light on a puzzle that is posed by some attempts to ground religious commitments in moral commitments. In all of these ways, the notion of supererogation turns out to be key for an appreciation of the distinctive character of a religious vision of human life. (shrink)

This paper explores some implications of the idea that religious thoughts can enter into the sensory appearances of things. I begin by clarifying this idea, using some examples drawn from Roger Scruton's discussion of the phenomenology of architectural experience. Then I consider the bearing of the idea on the case for religious belief in pragmatic and epistemic terms. More exactly, I explore how the idea of an internal relation between religious thought and the sensory appearances of things can be used (...) (1) to state William James's case in 'The will to believe' with new nuance, and (2) to set out an epistemic case for religious belief whose central claims seem quite commonly to weigh with believers, but which has not been much discussed by philosophers. (shrink)